Frontal dysfunction contributes to the genesis of hallucinations in non‐demented Parkinsonian patients
Identifieur interne : 001493 ( Main/Exploration ); précédent : 001492; suivant : 001494Frontal dysfunction contributes to the genesis of hallucinations in non‐demented Parkinsonian patients
Auteurs : Dario Grossi [Italie] ; Luigi Trojano [Italie] ; Maria Teresa Pellecchia [Italie] ; Marianna Amboni [Italie] ; Nina Antonetta Fragassi [Italie] ; Paolo Barone [Italie]Source :
- International Journal of Geriatric Psychiatry [ 0885-6230 ] ; 2005-07.
English descriptors
Abstract
Background: Hallucinations occur in patients with Parkinson's disease (PD) with reported prevalence ranging from 8% to 40%. Hallucinations are significantly associated with dementia in PD, but little is known about possible distinctive cognitive features of non‐demented PD patients who develop hallucinations. Objective: The aim of the study was to assess selected cognitive abilities in non‐demented PD patients with and without hallucinations in order to identify specific neuropsychological correlates of such phenomena. Methods: Forty‐eight consecutive patients with PD and Mini Mental State Examination (MMSE) ≥ 23 were examined for the presence of hallucinations and assessed on standardized neuropsychological tasks for semantic and phonological fluency, verbal learning and logical abstract thinking; disease severity was staged according to Hoehn and Yahr scale. Results: Fourteen (29.2%) of 48 patients experienced hallucinations. There was no difference between hallucinators and non‐hallucinators on demographic variables, disease severity and dose of any pharmacological treatment. Disease duration was significantly longer in hallucinator vs non‐hallucinator patients (p = 0.02). Patients with hallucinations scored significantly lower than patients without hallucinations only on verbal learning—immediate recall task (p = 0.0324), and semantic and phonological fluency tasks (p = 0.0005 and p = 0.0036, respectively). Conclusions: Our results suggest that PD patients with hallucinations show reduced performance on tasks that explore executive functioning as compared with non‐hallucinators. Therefore, executive dysfunction may be considered as a risk factor for the development of hallucinations in non‐demented PD patients. Copyright © 2005 John Wiley & Sons, Ltd.
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DOI: 10.1002/gps.1339
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J. Geriat. Psychiatry</title><idno type="ISSN">0885-6230</idno><idno type="eISSN">1099-1166</idno><imprint><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2005-07">2005-07</date><biblScope unit="volume">20</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="668">668</biblScope><biblScope unit="page" to="673">673</biblScope></imprint><idno type="ISSN">0885-6230</idno></series><idno type="istex">281CA461F2E7601CE9DAD0A28101EEABCE7AB044</idno><idno type="DOI">10.1002/gps.1339</idno><idno type="ArticleID">GPS1339</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-6230</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Executive functions</term><term>Frontal lobe</term><term>Hallucinations</term><term>Parkinson's disease</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Hallucinations occur in patients with Parkinson's disease (PD) with reported prevalence ranging from 8% to 40%. Hallucinations are significantly associated with dementia in PD, but little is known about possible distinctive cognitive features of non‐demented PD patients who develop hallucinations. Objective: The aim of the study was to assess selected cognitive abilities in non‐demented PD patients with and without hallucinations in order to identify specific neuropsychological correlates of such phenomena. Methods: Forty‐eight consecutive patients with PD and Mini Mental State Examination (MMSE) ≥ 23 were examined for the presence of hallucinations and assessed on standardized neuropsychological tasks for semantic and phonological fluency, verbal learning and logical abstract thinking; disease severity was staged according to Hoehn and Yahr scale. Results: Fourteen (29.2%) of 48 patients experienced hallucinations. There was no difference between hallucinators and non‐hallucinators on demographic variables, disease severity and dose of any pharmacological treatment. Disease duration was significantly longer in hallucinator vs non‐hallucinator patients (p = 0.02). Patients with hallucinations scored significantly lower than patients without hallucinations only on verbal learning—immediate recall task (p = 0.0324), and semantic and phonological fluency tasks (p = 0.0005 and p = 0.0036, respectively). Conclusions: Our results suggest that PD patients with hallucinations show reduced performance on tasks that explore executive functioning as compared with non‐hallucinators. Therefore, executive dysfunction may be considered as a risk factor for the development of hallucinations in non‐demented PD patients. Copyright © 2005 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Grossi, Dario" sort="Grossi, Dario" uniqKey="Grossi D" first="Dario" last="Grossi">Dario Grossi</name></noRegion><name sortKey="Amboni, Marianna" sort="Amboni, Marianna" uniqKey="Amboni M" first="Marianna" last="Amboni">Marianna Amboni</name><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><name sortKey="Fragassi, Nina Antonetta" sort="Fragassi, Nina Antonetta" uniqKey="Fragassi N" first="Nina Antonetta" last="Fragassi">Nina Antonetta Fragassi</name><name sortKey="Pellecchia, Maria Teresa" sort="Pellecchia, Maria Teresa" uniqKey="Pellecchia M" first="Maria Teresa" last="Pellecchia">Maria Teresa Pellecchia</name><name sortKey="Trojano, Luigi" sort="Trojano, Luigi" uniqKey="Trojano L" first="Luigi" last="Trojano">Luigi Trojano</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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